With the improvement of people’s material lives and changes in lifestyles, the prevalence of chronic diseases such as hypertension has shown a rapidly growing trend. Numerous animal and human fasting trials have reported that fasting has been emerging as an effective tool to control weight and lower blood pressure, having a profound health benefit. In a fasting trial involving 149 participants in China, the subjects’ body weight, BMI (body mass index) and waist circumference all significantly decreased from baseline after 5 consecutive days of fasting intervention (P<0.001). The magnitude of systolic and diastolic blood pressure (BP) reduction in subjects with hypertension was -11.2 mmHg (-14.9 to -7.5 mmHg, 95% CI (confidence intervals), P<0.001) and -7.2 mmHg (-9.7 to -4.7, 95% CI, P<0.001) after 5-day fasting intervention, respectively. No significant reduction occurred in systolic and diastolic BP of participants with normal BP. Then we implemented a further assessment of antihypertensive effects during the period of fasting trial by developing an easy-to-use nomogram based on proportional hazards regression, and the nomogram in our study achieved a bootstrap-corrected concordance index (C-index) of 0.891.