Clinical Trials

VAT and Fasting Pilot Study

Recruitment for this study is from patients who voluntarily visit TrueNorth Health Center. We are not accepting outside inquiries for enrollment.

Excess visceral adipose tissue (VAT) is a strong indicator of insulin resistance, which is a risk factor for cardio-metabolic and inflammatory disorders. This pilot study will explore the effects of water-only fasting followed by an exclusively whole-plant-food diet free of salt, oil, and sugar on body composition with a particular focus on VAT. The study will also extend the Fasting for Brain and Heart Health Pilot Study, assessing the effects of fasting and refeeding on HOMA-IR values and markers of cardiovascular health and inflammation, by following participants for an additional six weeks.

Principle Investigators: Toshia Myers, PhD, Eugene L Scharf, MD and Alan Goldhamer, DC
Project Staff: Natasha Thompson, ND; Evelyn Zeiler, PhD; Sahmla Gabriel, MD; Mara Gilbert, RN; Faye Alexandrakis, DC; Haley Ramsey, MS; Rie Schur, ND; Ahmed Deen

Hypertension Safety and Feasibility Pilot Study

Recruitment for this study is from patients who voluntarily visit TrueNorth Health Center. We are not accepting outside inquiries for enrollment.

This study will assess the safety and feasibility of water-only fasting and refeeding for treatment of stage 1 and 2 hypertensive patients. Preliminary research suggests that water-only fasting efficiently lowers blood pressure and may effectively improve implementation of and adherence to lifestyle changes. Mean changes in resting blood pressure as well as markers of cardiovascular health and inflammation between baseline and end-of-fast, end-of-refeed, and six-weeks post departure will also be reported.

Principle Investigators: Toshia Myers, PhD, Eugene L Scharf, MD and Alan Goldhamer, DC
Project Staff: Justin Wise, ND; Natasha Thompson, ND; Evelyn Zeiler, PhD; Sahmla Gabriel, MD; Mara Gilbert, RN; Faye Alexandrakis, DC; Haley Ramsey, MS; Rie Schur, ND; Ahmed Deen

HOMA-IR & Fasting Pilot Study

This study is closed for recruitment and publication is in progress.

This pilot study is a prospective, observational study examining the effects of medically supervised, water-only fasting followed by an exclusively whole-plant-food refeeding diet on accepted measures of cardiovascular risk and metabolic health. The primary aim was to describe mean glucose tolerance as indicated by Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) scores at baseline, end-of-fast, and end-of-refeed visits. Secondary endpoints were to describe the effects of fasting and refeeding on markers of cardiovascular risk, including blood pressure, abdominal circumference, high-sensitivity CRP, and plasma lipoproteins. This study is being completed in collaboration with Dr. Eugene Scharf from The Mayo Clinic. 

Principle Investigators: Toshia Myers, PhD and Eugene L Scharf, MD
Project Staff: Patricia Kolbe, MA; Su-Yeon Hwang, PharmD; Mara Gilbert, RN; Faye Alexandrakis, DC; Natasha Thompson, ND; Evelyn Zeiler, PhD.

Taste Adaptation Pilot Study

This study is closed for recruitment and publication is in progress.

The Taste Adaptation Pilot Study was conducted in conjunction with the National University of Natural Medicine. The motivation behind this study is growing evidence that the over-consumption of sweet, fatty, and salty foods and the under-consumption of fruits and vegetables is a contributing factor to numerous chronic diseases. Our aim was to do a preliminary assessment to determine if water-only fasting affects taste sensitivity to salty and sweet tastes. We assessed if a change in taste sensitivity can be correlated to dietary preference and consumption.

Principle Investigators: Toshia Myers, PhD and Ryan Bradley, ND
Project Staff: Zrinka Glavas, MS; Daniella Densley, MD; Patricia Kolbe, MA; Su-Yeon Hwang, PharmD

Click here for our published research