A research article published in 2018 assesses the safety of water-only fasting for 768 patients over a 5-year-period by systematically assessing reported adverse events in fasting patients using the Common Terminology Criteria for Adverse Events (CTCAE). The data indicates the majority of adverse events are mild to moderate and typically known reactions to fasting. The study provides a protocol for researchers interested in conducting human-subjects research on the physiological and molecular mechanisms active during water fasting.

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